Fig. 4.

Prediction of effect of multiple vaccinations with increasing time between successive vaccinations. To examine the impact of the time between successive vaccinations, model predictions were obtained with adenovirus vaccination every 5 days (red lines), 10 days (aqua lines), 15 days (orange lines), 20 days (blue lines) with dose 1×10⁶ RLU per mm³ for 10 times following the initial vaccination with dose of 1.1×10⁶ RLU per mm³ on day 5 after tumor implantation. a TE1, b TE2, c TE3, d LV, e Total tumor cells (CMHCI+ + CMHCI-), f IFNG, g TNFA, and h TN