Table 1.

Organ and tissue weights at Day 11 and the end of study

Organ weight (mg)	Sham (n = 10)	Placebo Day 11 (n = 11)	Febuxostat Day 11 (n = 7)	Placebo final (n = 45)	Febuxostat final (n = 16)
Heart	893 ± 41**	636 ± 17	543 ± 15	553 ± 15	587 ± 29
Liver	11 292 ± 511**	7 480 ± 232	6 775 ± 359	5 640 ± 151	6 378 ± 675
Spleen	632 ± 32**	278 ± 29	302 ± 39	159 ± 8*	253 ± 44***
Kidney left	1 036 ± 26**	728 ± 18	692 ± 37	705 ± 18	752 ± 36
White adipose tissue	1 282 ± 173**	203 ± 85	136 ± 70	48 ± 28	501 ± 221***
Brown adipose tissue	311 ± 43**	100 ± 19	116 ± 15	95 ± 5	139 ± 16
Musculus gastrocnemius	1 426 ± 27**	953 ± 30	874 ± 51	795 ± 20	911 ± 83
Musculus tibialis	501 ± 7**	315 ± 14	318 ± 19	280 ± 7	312 ± 32
Musculus extensor digitalis longus	115 ± 6**	80 ± 4	77 ± 4	68 ± 1	83 ± 8***
Musculus soleus	121 ± 6*	91 ± 4	85 ± 5	76 ± 2	91 ± 7***

^*P < 0.01 vs. placebo Day 11;

^**P < 0.001 vs. placebo Day 11;

^***P < 0.05 vs. placebo final.