Table 3.
Percent inhibition at 3 IU/ml ASNase
| Cell line | dm HpA | wt HpA | L-ASP | ERWase |
|---|---|---|---|---|
| SupB15 | 92 | 92 | 93 | 92 |
| RS4;11 | 91 | 91 | 90 | 85 |
| MOLT-4 | 84 | 94* | 95* | 95* |
| SEM | 27 | 47** | 58** | 78** |
| BV173 | 6 | 32** | 35** | 66** |
| HL-60 | 12 | 33 | 31 | 62** |
| SD-1 | 0 | 15 | 34 | 67** |
| REH | 0 | 35** | 47** | 62** |
| RCH-ACV | 0 | 29** | 20** | 51** |
| NALM6 | 4 | 18 | 18 | 51** |
| K-562 | 0 | 0 | 0 | 32** |
The percentage of inhibition at 3 IU/ml was calculated from normalized data (Fig 2). Each ASNase isoforms was compared to untreated cells control using 2 way ANOVA with Bonferroni post-tests.
p<.05,
p<.01 vs. dm HpA; n = 4–5 for each cell line.