Fig. 9.
Effect of different free fatty acids on 2APB-evoked TRPV3 current in Xenopus oocytes. A: Oocytes expressing TRPV3 were held at −40 mV and stimulated with 300 μM 2APB without or with the pretreatment of 10 μM different free fatty acid as indicated. Shown are current amplitudes normalized to that obtained with 2APB plus 10 μM AA. Dashed line shows the response level to 2APB alone, based on the average increase induced by 10 μM AA for 300 μM 2APB at −40 mV. B: Structures of selected free polyunsaturated fatty acids.
