Figure 3. Macrophages and ferumoxytol uptake.

Macrophages incubated with and ferumoxytol and lipopolysaccharide were treated with either aspirin or vehicle for 24 hours. Immunohistochemistry demonstrates decrease uptake of ferumoxytol by the macrophages treated with aspirin. This supports the findings on ferumoxytol-MRI where patients treated with aspirin had decrease intensity of the signal on the T2 sequence suggesting decreased inflammation in the aneurysm wall.