Table 2.
Standardized incidence ratios of category-specific cancers in (A) 377 patients with CD and (B) 462 patients with UC, compared with expected numbers in a SEER-based age- and sex-matched general population, in Olmsted County, Minnesota, 1940–2011. Cancers were classified into 7 categories based on the primary site involved – intestinal cancer (including CRC, small intestinal, biliary tract, hepatocellular, gallbladder, pancreatic, gastric, esophageal and anal cancer), tobacco-related cancers (lung, head and neck including oral, bladder, kidney, and ureter), female reproductive organ cancers (ovarian, endometrial, cervical, vaginal/vulvar and breast), male reproductive organ cancers (testicular and prostate cancer), miscellaneous extra-intestinal cancers (prostate, brain, spinal cord, thyroid, melanoma), hematological cancers (Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, acute and chronic leukemia, multiple myeloma) and melanoma. Please note, figures in bold represent statistically significant results.
| (A) | ||||||
|---|---|---|---|---|---|---|
| Cancer Category | Males | Females | Overall | |||
| Observed | Expected | Observed | Expected | SIR | 95% CI | |
| Intestinal cancers | 6 | 4.03 | 5 | 4.01 | 1.37 | 0.68–2.45 |
| Tobacco-related cancers | 7 | 6.06 | 5 | 4.40 | 1.15 | 0.59–2.00 |
| Male reproductive organ cancers | 7 | 6.00 | NA | NA | 1.17 | 0.47–2.40 |
| Female reproductive organ cancers | NA | NA | 12 | 9.65 | 1.24 | 0.64–2.17 |
| Miscellaneous extra-intestinal solid organ cancers | 2 | 0.92 | 3 | 0.97 | 2.64 | 0.86–6.15 |
| Hematological malignancies | 3 | 0.92 | 3 | 0.97 | 3.17 | 1.16–6.89 |
| Melanoma | 4 | 0.89 | 1 | 0.98 | 2.67 | 0.87–6.23 |
| (B) | ||||||
|---|---|---|---|---|---|---|
| Cancer Category | Males | Females | Overall | |||
| Observed | Expected | Observed | Expected | SIR | 95% CI | |
| Intestinal cancers | 6 | 9.08 | 7 | 5.51 | 0.89 | 0.47–1.52 |
| Tobacco-related cancers | 11 | 14.06 | 3 | 5.95 | 0.70 | 0.38–1.17 |
| Male reproductive organ cancers | 14 | 13.14 | NA | NA | 1.07 | 0.58–1.79 |
| Female reproductive organ cancers | NA | NA | 15 | 12.09 | 1.24 | 0.69–2.05 |
| Miscellaneous extra-intestinal solid organ cancers | 2 | 1.86 | 2 | 1.12 | 1.34 | 0.37–3.44 |
| Hematological malignancies | 5 | 1.86 | 3 | 1.12 | 2.69 | 1.16–5.29 |
| Melanoma | 4 | 1.84 | 2 | 1.13 | 2.02 | 0.74–4.40 |
SIR, standardized incidence ratio; 95% CI, 95% confidence interval.