Table 2.

Association of BPD defined as either oxygen dependency at 28 days or at 36 weeks PMA with respiratory outcomes

(a) Analysis using the data from the development cohort (n=76)
i) Oxygen dependency at 28 days (BPD28d)
Respiratory outcome at 24 months corrected age		OR (95% CI)	P-value	Area under ROC curve
Respiratory hospital admission	61	3.89 (0.45, 33.6)	0.22	0.55
Cough	60	2.66 (0.50, 14.1)	0.25	0.56
Wheeze	61	1.85 (0.35, 9.86)	0.47	0.54
Respiratory medications (all types)	60	1.52 (0.37, 6.33)	0.56	0.53
Any cough, wheeze and/or use of respiratory medications	61	1.58 (0.38, 6.55)	0.53	0.53
ii) Oxygen dependency at 36 wk PMA (BPD36w)
Respiratory outcome at 24 months corrected age		OR (95% CI)	P-value	Area under ROC curve
Respiratory hospital admission	61	1.58 (0.50, 5.00)	0.43	0.55
Cough	60	2.43 (0.81, 7.27)	0.11	0.60
Wheeze	61	2.02 (0.65, 6.28)	0.23	0.58
Respiratory Medications (all types)	60	3.41 (1.16, 9.98)	0.025	0.65
Any cough, wheeze and/or use of respiratory medications	61	2.65 (0.93, 7.58)	0.069	0.62

(b) Analysis using data from the validation cohort with four week diary card results (n=227)
i) Oxygen dependency at 28 days (BPD28d)
Respiratory outcome at 24 months corrected age	N	OR (95% CI)	P-value	Area under ROC curve
Respiratory hospital admission	225	0.94 (0.38, 2.32)	0.90	0.50
Cough	226	1.22 (0.60, 2.48)	0.59	0.51
Wheeze	217	1.72 (0.80, 3.71)	0.17	0.54
Respiratory medications (all types)	227	1.97 (0.97, 4.01)	0.062	0.55
Any cough, wheeze and/or use of respiratory medications	227	1.56 (0.77, 3.18)	0.22	0.53
ii) Oxygen dependency at 36 wk PMA (BPD36w)
Respiratory outcome at 24 months corrected age	N	OR (95% CI)	P-value	Area under ROC curve
Respiratory hospital admission	225	1.41 (0.69, 2.90)	0.35	0.54
Cough	226	1.10 (0.64, 1.88)	0.73	0.51
Wheeze	217	0.90 (0.51, 1.56)	0.70	0.51
Respiratory Medications (all types)	227	1.55 (0.90, 2.66)	0.12	0.55
Any cough, wheeze and/or use of respiratory medications	227	1.33 (0.76, 2.31)	0.31	0.53

^*Difference is BPD versus no BPD

^**P-value from t-test