Table 4.

Comparison of ROC areas of RM₁, RM₂, BPD_28d and BPD_36w with respiratory outcomes at 24 months corrected age

(a) Analysis using data from the development cohort (n=76)
Respiratory outcome at 24 months	N	Area under ROC curve
		RM1	BPD28d *	P-value	BPD36w *	P-value
Respiratory hospital admission	52	0.64	0.55	0.33	0.52	0.26
Cough	51	0.77	0.54	0.0008	0.57	0.027
Wheeze	52	0.70	0.51	0.015	0.54	0.086
Respiratory medications (all types)	51	0.73	0.49	0.0017	0.60	0.18
Any cough, wheeze and/or use of respiratory medications	52	0.75	0.50	0.0004	0.57	0.042
Respiratory outcome at 24 months	N	Area under ROC curve
		RM2	BPD28d *	P-value	BPD36w *	P-value
Respiratory hospital admission	52	0.70	0.55	0.067	0.52	0.065
Cough	51	0.77	0.54	0.0008	0.57	0.030
Wheeze	52	0.68	0.51	0.036	0.54	0.16
Respiratory medications (all types)	51	0.76	0.49	0.0001	0.60	0.084
Any cough, wheeze and/or use of respiratory medications	52	0.78	0.50	<0.001	0.57	0.012

(b) Analysis using data from the validation cohort with four week diary card results (n=227)
Respiratory outcome at 24 months	N	Area under ROC curve
		RM1	BPD28d	P-value	BPD36w	P-value
Respiratory hospital admission	225	0.69	0.50	< 0.001	0.54	0.003
Cough	226	0.69	0.51	< 0.001	0.51	< 0.001
Wheeze	217	0.69	0.54	< 0.001	0.51	< 0.001
Respiratory medications (all types)	227	0.73	0.55	< 0.001	0.55	< 0.001
Any cough, wheeze and/or use of respiratory medications	227	0.72	0.53	< 0.001	0.53	< 0.001
Respiratory outcome at 24 months	N	Area under ROC curve
		RM2	BPD28d	P-value	BPD36w	P-value
Respiratory hospital admission	225	0.66	0.50	0.0003	0.54	0.017
Cough	226	0.69	0.51	< 0.001	0.51	< 0.001
Wheeze	217	0.70	0.54	< 0.001	0.51	< 0.001
Respiratory medications (all types)	227	0.74	0.55	< 0.001	0.55	< 0.001
Any cough, wheeze and/or use of respiratory medications	227	0.73	0.53	< 0.001	0.53	< 0.001

^*Note these values are different from Table 2 since the group of children included in this analysis is smaller