Table 6.
Sensitivity, specificity, positive predictive value and negative predictive value for the RM1 and RM2and the respiratory outcome at 24 months
| (a) Analysis using data from the development cohort (n=76) | ||||||||
|---|---|---|---|---|---|---|---|---|
| RM1 | RM2 | |||||||
| Respiratory outcome at 24 months | Sensitivity (95% CI) | Specificity (95% CI) | Positive Predictive Value (95% CI) | Negative Predictive Value (95%CI) | Sensitivity (95% CI) | Specificity (95% CI) | Positive Predictive Value (95% CI) | Negative Predictive Value (95% CI) |
| Respiratory hospital admission | 69% (41, 89%) | 58% (41, 75%) | 42% (23, 63%) | 81% (61, 93%) | 69% (41, 89%) | 72% (55, 86%) | 52% (30, 74%) | 84% (66, 95%) |
| Cough | 81% (58, 95%) | 73% (54, 88%) | 68% (47, 85%) | 85% (65, 96%) | 71% (48, 89%) | 83% (65, 94%) | 75% (51, 91%) | 81% (63, 93%) |
| Wheeze | 77% (50, 93%) | 63% (45, 79%) | 50% (30, 70%) | 85% (65, 96%) | 65% (38, 86%) | 71% (54, 85%) | 52% (30, 74%) | 81% (63, 93%) |
| Respiratory medications (all types) | 71% (51, 87%) | 74% (52, 90%) | 77% (56, 91%) | 68% (47, 85%) | 64% (44, 81%) | 87% (66, 97%) | 86% (64, 97%) | 67% (47, 83%) |
| Any cough, wheeze and/or use of respiratory medications | 72% (53, 87%) | 78% (56, 93%) | 81% (61, 93%) | 69% (48, 86%) | 66% (46, 82%) | 91% (72, 99%) | 91% (70, 99%) | 68% (49, 83%) |
| (b) Analysis using data from the validation cohort with results from the four week diary card (n=227) | ||||||||
|---|---|---|---|---|---|---|---|---|
| RM1 | RM2 | |||||||
| Respiratory outcome at 24 months | Sensitivity (95% CI) | Specificity (95% CI) | Positive Predictive Value (95% CI) | Negative Predictive Value (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | Positive Predictive Value (95% CI) | Negative Predictive Value (95% CI) |
| Respiratory hospital admission | 76% (61, 88%) | 61% (54, 68%) | 31% (22, 41%) | 92% (85, 96%) | 67% (51, 80%) | 66% (59, 73%) | 31% (22, 42%) | 90% (83, 94%) |
| Cough | 66% (57, 75%) | 72% (63, 80%) | 68% (58, 77%) | 71% (62, 78%) | 61% (51, 70%) | 78% (70, 85%) | 71% (61, 80%) | 69% (60, 77%) |
| Wheeze | 69% (58, 78%) | 70% (62, 78%) | 62% (51, 71%) | 76% (68, 84%) | 64% (53, 74%) | 77% (68, 84%) | 66% (55, 75%) | 75% (67, 83%) |
| Respiratory medications (all types) | 66% (57, 74%) | 80% (71, 88%) | 82% (73, 89%) | 64% (55, 72%) | 61% (52, 69%) | 87% (78, 93%) | 86% (77, 92%) | 62% (54, 70%) |
| Any cough, wheeze and/or use of respiratory medications | 62% (54, 70%) | 81% (71, 89%) | 85% (76, 91%) | 56% (47, 65%) | 57% (49, 66%) | 88% (79, 94%) | 89% (81, 95%) | 55% (46, 63%) |