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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Nat Med. 2015 May 11;21(6):601–609. doi: 10.1038/nm.3843

Figure 5.

Figure 5

Dymamin oligomerization has beneficial effect on kidney morphology in PKCεKO mice. (a) Proteinuria in PKCεKO mice without treatment or treated with either DMSO (1%, vehicle) or with Bis-T-23 (40 mg/kg) once daily for 8 consecutive days (n = 6 mice per condition) as determined by analysis of the spot urine. Animals were 12 weeks old at the beginning of the treatment (day 0, D0). Error bars, mean ± SD (*P ≤ 0.05; **P ≤ 0.01; ***P ≤ 0.001; unpaired t-test). (b) Total of 150 glomeruli from different animals per group (n = 3) were scored in a blind manner: I = normal glomerulus, II = mild mesangial expansion, III = moderate mesangial expansion, IV = advanced mesangial matrix expansion. (c) Representative images of PAS-stained glomeruli (n = 150 glomeruli per condition) of 14-week-old untreated, DMSO- (1%) and Bis-T-23- (40 mg/kg) treated animals. Scale bars, 20 μm. (d) Representative TEM images of glomeruli (n = 10 glomeruli per group) from wild-type and PKCεKO mice harvested after 8 days of injection with either DMSO (1%, vehicle) or Bis-T-23 (40 mg/kg). Scale bars, 2 μm.