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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Drug Alcohol Depend. 2015 Apr 22;152:147–156. doi: 10.1016/j.drugalcdep.2015.04.009

Figure 2. Effect of cocaine exposure on the relative abundance of phospholipids in the hippocampus.

Figure 2

Rats were treated with either saline or cocaine as described in Figure 1A. Seven days after the final treatment (Day 22) hippocampal tissue was isolated, subjected to Bligh-Dyer extraction and analyzed by ESI-MS. A. represents positive ion ESI-MS spectra from control rats while B. represents positive ion ESI-MS spectra from cocaine exposed rats. C. represents changes in the relative abundance of select phospholipids in cocaine treated rats compared to saline controls and is presented as the mean ± the SD of at least 6 different rats. *Indicates a significant difference (p < 0.05) as compared to saline control rats. Lipid species indicated by only their m/z value were unable to be fully identified by subsequent MS/MS and neutral loss scanning.