Table 1.
Characteristics of study participants at baseline, by LVH and initial hs cTnT (N=2347)
| No LVH | LVH | |||||||
|---|---|---|---|---|---|---|---|---|
| Tertile 1 | Tertile2 | Tertile 3 | Test for trend |
Tertile 1 | Tertile2 | Tertile 3 | Test for trend |
|
| N | 932 | 584 | 535 | 87 | 79 | 128 | ||
| Range (pg/mL)* | ||||||||
| Men | <3.00 – 4.82 | 4.84 – 9.23 | 9.32 – 43.89 | <3.00 – 4.73 | 5.29 – 7.78 | 9.80 – 49.60 | ||
| Women | <3.00 | 3.00 – 6.00 | 6.02 – 36.12 | <3.00 | 3.12 – 5.98 | 6.55 – 71.82 | ||
| Age (years) | 71.2 (4.6) | 72.7 (5.1) | 73.1 (5.6) | <.001 | 71.5 (4.4) | 73.7 (5.8) | 73.8 (5.9) | .006 |
| Male | 247 (26.5%) | 250 (42.8%) | 216 (40.4%) | 24 (27.6%) | 29 (36.7%) | 61 (47.7%) | ||
| African-American | 143 (15.4%) | 74 (12.7%) | 88 (16.5%) | 0.8 | 12 (13.8%) | 8 (10.1%) | 16 (12.5%) | 0.8 |
| Diabetes | 92 (9.8%) | 90 (15.4%) | 119 (22.2%) | <.001 | 12 (13.8%) | 9 (11.4%) | 28 (21.9%) | .01 |
| Coronary Heart Disease | 78 (8.4%) | 65 (11.1%) | 58 (10.8%) | 0.09 | 7 (8.0%) | 15 (20.3%) | 21 (16.4%) | 0.13 |
| Body Mass Index | 26.1 (4.1) | 26.3 (4.4) | 27.0 (4.8) | <.001 | 26.4 (4.4) | 27.4 (4.7) | 27.1 (4.7) | 0.5 |
| SBP | 132.4 (19.8) | 133.6 (20.3) | 140.1 (22.5) | <.001 | 139.2 (22.8) | 143.8 (19.6) | 144.9 (24.0) | .07 |
| DBP | 70.2 (10.3) | 70.4 (10.8) | 71.4 (11.4) | 0.06 | 71.4 (11.6) | 72.2 (11.2) | 70.9 (13.2) | 0.7 |
| HTNive medications | 330 (35.4%) | 245 (42.0%) | 277 (52.0%) | <.001 | 39 (44.8%) | 46 (58.3%) | 76 (59.4%) | .04 |
| Smoking | 0.9 | 0.12 | ||||||
| Current | 112 (12.0%) | 51 (8.7%) | 51 (9.6%) | 13 (13.9%) | 6 (7.6%) | 16 (12.5%) | ||
| Former | 363 (39.0%) | 260 (44.6%) | 208 (39.0%) | 24 (27.6%) | 25 (31.7%) | 55 (43.0%) | ||
| Never | 455 (48.9%) | 272 (46.7%) | 275 (51.5%) | 50 (57.5%) | 48 (60.8%) | 57 (44.5%) | ||
| eGFRMDRD<60 | 132 (14.2%) | 100 (17.1%) | 148 (27.7%) | <001 | 8 (9.2%) | 17 (21.5%) | 41 (32.0%) | <.001 |
| Abnormal LVEF† | 4 (0.4%) | 5 (0.9%) | 7 (1.3%) | .06 | 1 (1.2%) | 2 (2.5%) | 14 (10.9%) | .002 |
| Relative Wall Thickness | 0.34 [0.30, 0.39] | 0.35 [0.30, 0.40] | 0.35 [0.30, 0.40] | 0.003 | 0.35 [0.28, 0.43] | 0.38 [0.31, 0.42] | 0.37 [0.30, 0.43] | 0.06 |
| LVMI (g/m2) | ||||||||
| Male | 82.6 [71.5, 92.9] | 82.7 [68.5, 96.2] | 81.6 [69.8, 95.3] | 0.9 | 129.2 [119.8, 147.5] | 131.7 [126.2, 138.8] | 128.5 [121.4, 152.4 | 0.9 |
| Female | 71.3 [62.4, 80.5] | 72.4 [61.7, 81.7] | 73.8 [64.2, 85.1] | .04 | 106.4 [103.0, 122.4] | 112.8 [103.4, 121.0] | 113.1 [104.7, 123.1] | 0.1 |
Cell values represent mean (SD), N(%), or median[interquartile range].
*
Biomarker categories are stratified by age and gender; range for age 70–75 years shown.
†
LVEF<45% on initial echocardiogram.