Table 5.
Risk of Incident HF with reduced EF, by LVH and change in biomarker levels (N=1474)
| Hazard Ratios (95% CI) | ||||
|---|---|---|---|---|
| LVH by Echo |
Increase in NT-proBNP |
% of LVH subgroup |
Baseline- adjusted |
Risk-factor adjusted |
| None | No | 1046 (81.7%) | 1.0 | 1.0 |
| Yes | 235 (18.3%) | 1.17 (0.60, 2.29) | 1.14 (0.55, 2.35) | |
| Yes | No | 129 (66.8%) | 2.08 (1.07, 4.06) | 1.99 (0.97, 4.08) |
| Yes | 64 (33.2%) | 4.77 (2.36, 9.77) | 3.46 (1.56, 7.65) | |
| LVH by Echo |
Increase in hs cTnT |
% of LVH subgroup |
Baseline- adjusted |
Risk-factor adjusted |
| None | No | 1062 (82.9%) | 1.0 | 1.0 |
| Yes | 219 (17.1%) | 2.65 (1.45, 4.86) | 2.48 (1.29, 4.77) | |
| Yes | No | 144 (74.6%) | 2.87 (1.53, 5.39) | 2.21 (1.08, 4.54) |
| Yes | 49 (25.4%) | 6.94 (3.22, 14.96) | 6.95 (3.07, 15.72) | |
Cell values are hazard ratios (95% CI) from Cox proportional hazards models. Hazard ratios adjusted for: baseline biomarker level, age, race, gender, smoking, hypertension, diabetes, coronary heart disease, body mass index, eGFR<60 cc/min/1.73m2, relative wall thickness and LVEF<45%.
Interaction between LVH and Change in NT-proBNP: p=0.5
Interaction between LVH and Change in hs-cTnT: p=0.7