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. Author manuscript; available in PMC: 2016 Mar 21.
Published in final edited form as: Neonatology. 2015 Mar 21;107(4):304–311. doi: 10.1159/000371835

Figure 5. CXCR4 Blockade Decreases Inflammation in HILI.

Figure 5

A. Reduced BAL macrophage counts in hyperoxia-AMD3100 rats (*p<0.0001; RA-PL vs. hyperoxia-PL; **p<0.0001; hyperoxia-PL vs. hyperoxia-AMD3100; n=5/group). White bars represent RA animals and black bars represent hyperoxia animals.

B. Decreased BAL neutrophil counts in hyperoxia-AMD3100 rats (*p<0.0001; RA-PL vs. hyperoxia-PL; **p<0.0001; hyperoxia-PL vs. hyperoxia-AMD3100, n=5/group).

C. Reduced lung myeloperoxidase (MPO) activity in hyperoxia-AMD3100 rats (*p<0.0001; RAPL vs. hyperoxia-PL; **p<0.02; hyperoxia-PL vs. hyperoxia-AMD3100; n=5/group).

D. Decreased lung MMP-9 protein expression in hyperoxia-AMD3100 rats (*p <0.05; RA-PL vs. hyperoxia-PL; **p<0.05; hyperoxia-PL vs. hyperoxia-AMD3100; n=5/group). RA is room air and HYP is hyperoxia. MMP-9 expression is normalized to β-actin.