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. Author manuscript; available in PMC: 2016 Jun 4.
Published in final edited form as: Cell. 2015 May 21;161(6):1345–1360. doi: 10.1016/j.cell.2015.04.048

Figure 5. Runx3 inhibits proliferation in invasive PDA cells.

Figure 5

(A and B) Ki-67 expression in autochthonous (A) KPDC and (B) KPC PDA.

(C and D) Cleaved caspase 3 in autochthonous (C) KPDC and (D) KPC PDA.

(E) Proliferation in autochthonous KPDC and KPC tumors (mean ± SEM, *p<0.05).

(F) Proliferation of purified PDA cells ±TGFβ in vitro (n=3, mean ± SEM; *p<0.001).

(G) Proliferation of control (Scr) and Runx3-knockdown (shRunx3) purified primary KPC cells in vitro (n=3, mean ± SEM; *p<0.001).

(H) Proliferation of control (Flag) and Runx3-overexpressing (Fl-Runx3) purified KPDC cells in vitro (n=3, mean ± SEM; *p<0.001).

(I) Immunoblots for p21 in control and Runx3-overexpressing KPDC cells and control and Runx3-depleted KPC cells. Fold changes were quantified by densitometry and normalized to actin. Scale bars, 50 μm.