Table 1.
Clusterwise corrected p-values for ROI and Whole-brain analyses. (n = 12)
| CC > BL
|
E(C) > BL
|
CC > E(C)
|
E(C) > CC
|
CC post-stimulation
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ROI
|
Whole brain
|
ROI
|
Whole brain
|
ROI
|
Whole brain
|
ROI
|
Whole brain
|
ROI
|
Whole brain
|
|||||
| ↑ | ↓ | ↑ | ↓ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↓ | ↑ | ↓ | |
| Brainstem | ◆ | ◆ | ◆ | ◆ | ◆ | |||||||||
| dorsal raphe | b*** | u | u | u | b*** | u | b*** | u | u | |||||
| hypoglossal | l*** | u | u | u | l*** | u | l*** | u | u | |||||
| locus coeruleus | b*** | u | u | u | b*** | u | b*** | u | u | |||||
| nucleus cuneatus | u | u | u | l** | u | u | u | u | u | |||||
| parabrachial area | r*** | u | u | u | r*** | u | r*** | u | u | |||||
| periaqueductal gray | b*** | u | u | u | b*** | u | b*** | u | u | |||||
| principal spinal trigeminal nucleus | b*** | u | u | u | b*** | u | u | u | u | |||||
| red nucleus | b*** | u | u | u | b*** | u | b*** | u | u | |||||
| solitary nucleus | l*** | u | u | u | l*** | u | l*** | u | u | |||||
| spinal trigeminal nucleus | b*** | u | u | l** | b*** | u | l*** | u | u | |||||
| substantia nigra | b*** | u | u | u | b*** | u | b*** | u | u | |||||
| ventral medulla | b*** | u | u | l** | u | b*** | u | u | u | |||||
| Forebrain | ||||||||||||||
| amygdala | r*** | u | r*** | u | u | u | r*** | r*** | u | u | r*** | u | u | u |
| anterior cingulate | ni | ni | b*** | u | ni | u | ni | b*** | ni | u | ni | ni | u | b** |
| bed nucleus of the stria terminalis | b*** | u | b*** | u | u | u | b*** | b*** | u | u | u | u | u | u |
| caudate | ni | ni | r*** | u | ni | u | ni | u | ni | u | ni | ni | l*** | u |
| cerebellum | ni | ni | b*** | u | ni | r** | ni | b*** | ni | u | ni | ni | b** | u |
| fornix | b*** | u | b*** | u | u | u | b*** | b*** | u | u | u | u | u | u |
| hippocampus | u | b*** | u | b*** | u | u | u | u | u | u | b*** | u | l*** | u |
| hypothalamus | u | b*** | u | b*** | u | u | u | u | u | u | u | u | u | u |
| insula | b*** | u | b*** | u | r* | r*** | b*** | b*** | u | u | b*** | u | r*** | u |
| nucleus accumbens | r *** | u | b*** | u | u | u | r*** | r*** | u | u | l*** | r*** | u | u |
| orbital frontal cortex | ni | ni | b*** | u | ni | u | ni | r* | ni | u | ni | ni | u | u |
| paracentral lobule | b* | u | b*** | u | u | u | b*** | b*** | u | u | u | b*** | u | b** |
| postcentral gyrus | b*** | u | b*** | u | b* | u | b* | b*** | u | u | u | u | u | b** |
| putamen | ni | ni | r*** | u | ni | u | ni | u | ni | u | ni | ni | r*** | u |
| stria terminalis | b*** | u | b*** | u | u | u | b*** | b*** | u | u | u | u | u | u |
| 1 | ||||||||||||||
| thalamus | b*** | u | b*** | u | u | u | b*** | b*** | u | u | b*** | u | b** | u |
CC = cymba conchae stimulation
E(C) = earlobe (control) stimulation
BL = baseline
◆ = Widespread activity throughout brainstem (corrected, p<0.0001)
1
bilateral thalamic activations found specifically within anterior thalamic nuclei
↑ = activation
↓= deactivation
*
= p < 0.04
**
= p < 0.01
***
= p < 0.0001
r = right
l = left
b = bilateral
u = undetected
ni = region not included in ROI analysis