Figure 4.
Effects of 1-butanol on phospholipase D activity and glucose metabolism stimulation by insulin in the isolated hepatocytes. (a) Phospholipase D activity, (b) uptake of 2-D-[3H]glucose, (c) incorporation of D-[U 14C]glucose into glycogen. Effect of insulin on phospholipase D activity and glucose metabolism in the 1-butanol- or 2-butanol-pretreated hepatocytes was determined as described in the Methods. ∗ p < 0.05, insulin versus control; ∗∗ p < 0.05, insulin + 1-butanol versus insulin + 2-butanol; ∗∗∗ p < 0.05, 1-butanol versus 2-butanol.