Fig. 2.

Immunofluorescence labeling for huntingtin (Ht) in the rat striatum viewed with CLSM. Two low-magnification fields (A, B) and two high-magnification fields (C, D) show that scattered large neurons intensely labeled for huntingtin and numerous medium-sized neurons moderately labeled for huntingtin are present in striatum. Magnification in A is as in B; magnification in C is as in D. Images E and F show immunofluorescence labeling for huntingtin in the lower layers of rat cerebral cortex, at increasingly higher magnification. Both fields show intense labeling of pyramidal neurons in Layer 5 of cortex. All images are from Fusco et al. (1999).