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. Author manuscript; available in PMC: 2015 Jun 7.
Published in final edited form as: Int Rev Neurobiol. 2011;98:325–372. doi: 10.1016/B978-0-12-381328-2.00014-6

Fig. 3.

Fig. 3

Images showing immunolabeling for huntingtin in HD brain, revealing aggregates of mutant huntingtin in neuronal nuclei, termed intranuclear inclusions (NIIs). Image A shows the presence of numerous NIIs in cerebral cortex of juvenile HD victim at low magnification. Images B and C show immunolabeled NIIs in individual cortical pyramidal neurons in the same juvenile HD victim, using Nomarski optics to highlight the NIIs. The nucleolus in each cell is unlabeled. These images are adapted from A-C of Fig. 1 from DiFiglia et al. (1997).