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. Author manuscript; available in PMC: 2015 Jun 7.
Published in final edited form as: Neuroscience. 2012 Oct 2;227:119–133. doi: 10.1016/j.neuroscience.2012.09.054

Figure 6.

Figure 6

Treatment with fixed-spaced stimulation prevents capsaicin-induced EMR when administered 24 hr prior to capsaicin. After baseline tactile reactivity was assessed, subjects received 900 fixed spaced legshocks, 900 variable shocks, or nothing (Unshk). Tactile reactivity was then re-assessed (Postshock). The next day, after tactile reactivity was measured (Preinjection), rats received a subcutaneous hindpaw injection of 1% capsaicin (50 μL) in the previously treated leg. Tactile reactivity was then assessed over a period of 3 hr (Postinjection). (A–C) Tactile reactivity after shock treatment. (D–F) Tactile reactivity 24 hr after shock treatment. (G–I) Tactile reactivity after capsaicin treatment, averaged over the 3 hr test period. In each set of panels, data are presented for the Treated Leg (left), Untreated Leg (center), and average across legs (Means, right). Asterisks indicate statistically significant differences (p < .05), and error bars depict ± SEM. The inset depicts the experimental design.