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. Author manuscript; available in PMC: 2016 Jul 10.
Published in final edited form as: J Control Release. 2015 Apr 30;209:280–287. doi: 10.1016/j.jconrel.2015.04.040

Figure 1. Distribution of MPP administered in sodium-based solutions with various osmolalities.

Figure 1

(A) Distribution of 60 nm MPP in transverse colorectal cryosections 5-10 min after intrarectal administration in DI water (20 mOsm); sodium-based tris buffers (TBS) with osmolalities of 260, 350, 450, and 860 mOsm; 5% glycerol in DI water (600 mOsm); 0.9% saline (300 mOsm, “normal saline”); Fleet Naturals® (260 mOsm); and regular Fleet® (2200 mOsm). Cell nuclei in transverse crysections were stained with DAPI. White scale bars = 300 μm. Images are representative of n ≥ 3 mice. (B) Quantified surface coverage of MPP administered in various solutions on flattened mouse colorectal tissue. Data are calculated as means ± SEM. *P < 0.05 as compared to DI water (20 mOsm), Student's t-test.