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. Author manuscript; available in PMC: 2016 Jul 10.
Published in final edited form as: J Control Release. 2015 Apr 30;209:280–287. doi: 10.1016/j.jconrel.2015.04.040

Figure 2. The impact of potassium on the colorectal distribution of MPP.

Figure 2

(A) Distribution of 60 nm MPP in transverse colorectal cryosections 5-10 min after intrarectal administration in DI water (20 mOsm), potassium phosphate buffer (K+ buffer, 150 mOsm), and sodium-based tris buffer (Na+ buffer, 150 mOsm). Cell nuclei in transverse crysections are stained with DAPI. Images are representative of n ≥ 3 mice. White scale bars = 300 μm. (B) Quantified surface coverage of MPP administered in potassium phosphate buffers with various osmolalities on mouse colorectal tissue. The images in (A) are illustrative of the difference in distribution of MPP after administration in sodium and potassium based enemas, whereas the quantified surface coverage in (B) is only for potassium-based solutions. Data are calculated as means ± SEM. *P < 0.05 as compared to DI water (20 mOsm), Student's t-test.