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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Neuropharmacology. 2015 Jan 12;94:36–41. doi: 10.1016/j.neuropharm.2014.12.012

Figure 2. FRRFamide, FMRFamide, and Dynorphin A Modulation of Human ASIC1a.

Figure 2

Representative traces of human ASICa expressed in Xenopus oocytes showing the response to FRRFamide (A), FMRFamide (B), or Dynorphin A(1-17) (C), Note that all three peptided inhibit steady-sate desenitization of ASIC and allow activation after incubation with Ph 6.8. Only FMRF Famide and FRRFamide slow inactivation and induce a sustained current (red arrows). Dynorphin A, FRRF amide, and FMRFamide were applied fro two minutes at Ph 7.9 (50100μ) and during the Ph 6.8 condition solution indicated in grey boxes above the trace. The pH 5.0 test solution was applied for 30s as indicated in white boxes the trace.