(A) WT (n=5) and Tipe−/− mice (n=5) were fed with DSS-containing water for five days, followed by regular drinking water. Survival was monitored for two weeks after the start of DSS treatment. (B-E) WT and Tipe−/− mice were fed with DSS water for five days, followed by regular drinking water for two days. Body weight (B) and disease score (C) were recorded daily. On Day seven, mice were euthanized; colon length and weight (D, E, and F) were measured, and histopathological changes (G) in colon tissues were examined by microscopy following H&E staining. Data shown are representatives of at least three experiments. Scale bar in 2F, 1 mm and in 2G, 50 µm. *P<0.05.