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. Author manuscript; available in PMC: 2016 Jun 15.
Published in final edited form as: J Immunol. 2015 May 6;194(12):5743–5750. doi: 10.4049/jimmunol.1401987

Figure 1. TNFAIP8-knockout mice are resistant to lethal Listeria monocytogenes infection.

Figure 1

Wild type (n=5) and TNFAIP8 knockout mice (n=7) were infected with 2x105 CFUs of L. monocytogenes through the tail vein. (A) Mouse Kaplan-Meier survival curve after L. monocytogenes injection (P = 0.01). (B) Changes in body weight following infection (P = 0.04). Mice were sacrificed at day 3 post infection and their livers, spleens, and sera collected. (C) Spleen and liver bacterial load was measured by a colony-forming assay. (D) Serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT). (E) Serum TNFα and IL-6 levels were measured by ELISA. The results are representative of at least two independent experiments. N.S., not significant; * P < 0.05.