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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Transl Res. 2014 Dec 20;166(1):89–102. doi: 10.1016/j.trsl.2014.11.010

Figure 1. CCR7 expression and CCL19/CCL21-induced cellular changes.

Figure 1

A, CCR7 expression in DCs matured with LPS, OVA and TNF-α cocktail as compared to immature DCs. B, Chemotaxis in response to CCL19 in immature and mature DCs. C, intracellular Ca2+ Kinetics: Ca2+ mobilization and influx in response to CCL19 and CCL21 in immature and mature DCs. Stimuli were added at 90 sec. D, CCL19/CCL21 decreased the side-scatter in mature DCs suggesting some intracellular reorganization. E, forward scatter also decreased in the matured DCs with CCL19/CCL21 stimulation suggesting a decrease in the cell size. Data are representatives of 3 independent experiments.