Fig. 3.
Ki16425 attenuates LPS-induced accumulation of oxidized proteins in visceral organs of mice. Male C57BL/6 mice (n=6/group) were given i.p. DMSO (5% in PBS) or i.p. ki16425 (20 mg/kg body weight) 1 h before LPS administration (i.p. 5 mg/kg body weight). Liver (A, B) and kidney (C, D) tissues were collected after 4 h and protein oxidation was determined by immunoblotting. Intensities of immunoblots were analyzed with Image J software.
