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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Transl Res. 2015 Jan 31;166(1):80–88. doi: 10.1016/j.trsl.2015.01.008

Fig. 4.

Fig. 4

Ki16425 reduces the LPS-induced increase in caspase 3 cleavage in mice. Male C57BL/6 mice were given i.p. DMSO (5% in PBS) or i.p. ki16425 (20 mg/kg body weight) 1 h before LPS administration (i.p. 5 mg/kg body weight). Liver (A, B) and kidney (E, F) tissues were collected after 4 h and cleaved caspase 3 levels were determined by immunoblotting. Intensities of immunoblots were analyzed with Image J software. Cellular apoptosis was examined by TUNEL staining (C, liver; G, Kidney). Arrows show TUNEL positive cells. Scale bar: 100 µm. (D, H) Number of TUENL positive cells in each filed (n=3–6).