Skip to main content
. Author manuscript; available in PMC: 2016 Jun 15.
Published in final edited form as: J Immunol. 2015 May 15;194(12):5713–5724. doi: 10.4049/jimmunol.1500277

Figure 8. Autophagy inhibition increases kidney pathology after low-dose NTS administration.

Figure 8

B6 mice were injected with 3-MA (30mg/kg i/p) at day −2, −1, 0, +1, and +2 relative to i/v injection of low-dose NTS. Kidneys were collected at day 21 post-NTS administration and paraffin embedded kidney sections were stained with periodic acid–Schiff reagent and hematoxylin. The tissue from mice injected with 3-MA and NTS exhibited extensive nephritis with crescent formation and numerous tubular casts associated with tubule dilation and necrosis. Images are representative for 5 mice per group. Bars= 100 μm. Experiment was repeated three times with similar results.