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. Author manuscript; available in PMC: 2016 Jun 15.
Published in final edited form as: J Immunol. 2015 May 13;194(12):5595–5598. doi: 10.4049/jimmunol.1500623

Figure 4. Roles of sOPN and iOPN during LPS endotoxemia.

Figure 4

T cells and macrophages are separately localized in different zones in the spleen. OPN expression is upregulated by LPS in RPMs, and sOPN is secreted from LPS-stimulated RPMs in the first 3 h after LPS stimulation. sOPN is detected by integrin αv on the CD4+ T cell surface; and T cells start migrating towards macrophages. T cells then interact with macrophages to stimulate macrophage CD40 signaling pathway, in which intracellular osteopontin (iOPN) is essential for downregulation of macrophage TNF production (9).