Table 4.
Factors associated with poor prognosis∗ among 75 hospitalized adult patients with Clostridium difficile colitis according to univariate logistic regression.
| Variable | Poor prognosis group (n = 32) |
Good prognosis group (n = 43) | OR (95% CI) | P value |
|---|---|---|---|---|
| Age, years, median (IQR) | 59.0 (39.5–76.0) | 55.0 (35.0–67.0) | 1.008 (0.98–1.03) | 0.46 |
| Charlson comorbidity index, median (IQR) | 3.0 (2.0–5.0) | 2.0 (1.0–5.0) | 1.68 (0.66–4.24) | 0.22 |
| HIV infection | 3 (9.3) | 2 (4.6) | 2.12 (0.33–13.50) | 0.42 |
| Proton pump inhibitors use | 25 (78.1) | 28 (65.1) | 1.91 (0.67–5.44) | 0.22 |
| Enteral tube feeding | 19 (59.3) | 11 (25.5) | 4.25 (1.59–11.36) | 0.004 |
| Cytotoxic chemotherapy in the previous 6 weeks | 6 (18.7) | 13 (30.2) | 0.53 (0.17–1.60) | 0.26 |
| Hospitalization in the previous 6 months | 19 (59.3) | 30 (69.7) | 0.63 (0.24–1.65) | 0.35 |
| Gastrointestinal surgery in the previous 30 days | 5 (15.6) | 2 (4.6) | 3.79 (0.68–20.99) | 0.12 |
| Length of antibiotic treatment, days, median (IQR) | 10.0 (7.0–15.0) | 10.0 (7.0–14.0) | 1.07 (0.96–1.19) | 0.19 |
| Fever | 9 (28.1) | 8 (18.6) | 1.71 (0.57–5.08) | 0.33 |
| Lethargy | 2 (6.2) | 2 (4.6) | 1.36 (0.18–10.25) | 0.76 |
| Dehydration | 4 (12.5) | 5 (11.6) | 1.08 (0.26–4.41) | 0.90 |
| Tachycardia | 3 (9.3) | 2 (4.6) | 2.12 (0.33–13.50) | 0.42 |
| Abdominal pain | 8 (25.0) | 18 (41.8) | 0.46 (0.16–1.26) | 0.13 |
| Abdominal distension | 13 (40.6) | 11 (25.5) | 1.99 (0.74–5.32) | 0.17 |
| Anorexia | 2 (6.2) | 4 (9.3) | 0.65 (0.11–3.78) | 0.63 |
| Nausea | 2 (6.2) | 5 (11.6) | 0.50 (0.09–2.79) | 0.43 |
| Hematochezia | 1 (3.1) | 5 (11.6) | 0.24 (0.02–2.20) | 0.21 |
| Leukocytosis or leukopenia | 13 (40.6) | 25 (58.1) | 0.49 (0.19–1.24) | 0.13 |
| Initial serum creatinine, mg/dL, median (IQR) | 1.1 (0.7–3.05) | 0.8 (0.6–1.3) | 1.27 (0.93–1.72) | 0.12 |
| Initial plasma CPR, mg/L, median (IQR) | 63.0 (33.5–174.0) | 84.5 (47.0–157.0) | 0.99 (0.99–1.00) | 0.75 |
| Initial plasma albumin, g/dL, median (IQR) | 2.7 (2.3–3.3) | 3.2 (2.7–3.6) | 0.46 (0.21–1.03) | 0.06 |
| Initial serum lactate, mmol/L, median (IQR) | 1.1 (0.85–2.2) | 0.75 (0.6–0.95) | 0.40 (0.59–1.81) | 0.10 |
Data presented as n (%) unless otherwise indicated. CPR: C-reactive protein; OR: odds ratio; CI: confidence interval; IQR: interquartile range (P25–P75).
∗Composite endpoint that includes in-hospital mortality, ICU admission, and treatment failure.