Table 4.

Incremental BCVA letters gained at 6 months versus laser therapy alone (random treatment effects model)

Treatment	Incremental letters gained vs laser photocoagulation alone
Ranibizumab 0.5 mg PRN	11.5 (7.5 to 15.9)*
Ranibizumab 0.5 mg PRN+laser photocoagulation	10.1 (5.1 to 15.3)*
Dexamethasone 0.7 mg implant	3.5 (−1.6 to 9.1)
Aflibercept 2q4	10.2 (4.6 to 15.5)*
Sham	1.0 (–3.5 to 5.9)

*p<0.05.

Studies included in the base case analysis are VIBRANT,¹² BRAVO,⁹ BRIGHTER,³² COMRADE-B,³³ Tan et al,²⁷ Battaglia Parodi et al,⁸ GENEVA.¹⁴

2q4, 2 mg monthly; BCVA, best corrected visual acuity; PRN, pro re nata (as needed).