Figure 4. Preferential electrical coupling between sister excitatory neurons is disrupted by clonal knockdown of DAB1.
See also Figure S4. (A–D) Quadruple whole-cell recordings of two sister excitatory neurons expressing EGFP/Vector alone (A, B) or EGFP/Dab1 shRNA-3 (C, D) (1 and 3, green) and two adjacent non-EGFP-expressing control excitatory neurons (2 and 4) in the neonatal neocortex. Scale bars: 20 μm (A, C); 500 pA, 100 msec, 5 pA (B, D). (E) Summary of the rate of electrical coupling observed between sister excitatory neurons expressing vector alone, Dab1 shRNA-1 or shRNA-3 and their adjacent non-sister excitatory neurons in the neocortex. ***, p < 0.001.