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Schematic diagram of cellular Ca fluxes during excitation-contraction coupling. Ca entry via L-type Ca channels triggers Ca-induced Ca release from the sarcoplasmic reticulum (SR), which results in myofilament activation. For relaxation, cytosolic Ca is transported into the SR via SR Ca-ATPase (SERCA2a) and into the extracellular space via sarcolemmal Na/Ca exchanger. Reproduced with permission from the AHA.184
