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. Author manuscript; available in PMC: 2016 Jun 5.
Published in final edited form as: Circ Res. 2015 Jun 5;116(12):1956–1970. doi: 10.1161/CIRCRESAHA.116.304678

Figure 4.

Figure 4

Characteristics of cardiac alternans. A) Simultaneous recordings of AP and intra-SR free [Ca] in isolated Langendorff-perfused rabbit hearts by optical mapping. At shorter pacing intervals (190 ms), alternans of the AP duration as well as SR Ca release alternans was observed. B) SR Ca release alternans can occur at heart rates where APD alternans is not yet detectable. C) Ca release alternans can be amplified by alternating changes in SR Ca load, i.e. SR Ca load alternans. Data reproduced with permission.43