Fig. 10.

A model for SecA2-dependent effects in M. tuberculosis. In the current model for SecA2-dependent protein export, the SecA2 ATPase promotes the export of select proteins across the cytoplasmic membrane through the SecYEG channel, possibly with the help of SecA1 (8, 19, 20). Proteins identified as being exported by the SecA2 pathway include examples with signal peptides (hatched rectangle) (i.e. SBPs) and examples lacking signal peptides (i.e. PknG). The SecA2-dependent proteins identified in this study are shown in the model with proteins identified as reduced in the ΔsecA2 mutant colored blue (i.e. PknG, SBPs, LipO, Mce, and Lpr) and proteins identified as increased in the ΔsecA2 mutant colored red (i.e. DosR-regulated proteins).