Table 4. H&E and Immunohistochemistry Assessment of other SN Pathologies. The table shows the types and frequencies of co-occurring brain pathologies in the SN of Dys and C subjects. Co-occurring brain pathologies were assessed by specific immunohistochemistry protocols for the following antigens: 1–42 β-amyloid, hyperphosphorylated-tau, α-synuclein, ubiq, and phosphorylated-TDP43. The lesions considered were 1–42 β-amyloid diffuse and neuritic plaques, hyperphosphorylated-tau positive NFTs, tau threads, and ubiq- and phosphorylated-TDP43-positive intraneuronal cytoplasmic inclusions.
Case# | 1–42 β-amyloid | Hyperphosphorylated-tau | α-synuclein | Ubiq-cytopl. incl./MB | Phosphorylated-TDP43 | H&E |
---|---|---|---|---|---|---|
1 (Dys) | Neg | Neg | Neg | Neg/Neg | Neg | Normal |
2 (Dys) | Neg | Neg | Neg | Neg/Pos | Neg | Normal |
3 (Dys) | Neg | Neg | Neg | Neg/Pos | Neg | Intimal thickening |
4 (Dys) | Neg | Neg | Neg | Neg/Neg | Neg | Normal |
5 (Dys) | Neg | Neg | Neg | Neg/Neg | Neg | Microhemorrhages |
6 (Dys) | Neg | NFT and Th (sparse), tau-glia | Neg | Neg/Pos | Neg | Normal |
7 (Dys) | Neg | NFT and Th (moderate) | Neg | Neg/Pos | Neg | Normal |
8 (Dys) | Neg | Th (moderate) | Pos (sparse) | Neg/Neg | Neg | Normal |
9 (Dys) | Neg | Neg | Neg | Neg/Neg | Neg | Normal |
10 (Dys) | Neg | NFT (rare) | Pos (rare) | Neg/Pos | Neg | Normal |
11 (Dys) | Neg | Th (sparse), pre-NFT (rare) | Pos (rare) | Neg/Neg | Neg | Normal |
12 (Dys) | Neg | Neg | Neg | Neg/Neg | Neg | Intimal thickening |
13 (Dys) | Neg | Neg | Neg | Neg/Pos | Neg | Intimal thickening |
14 (C) | Neg | Neg | Neg | Neg/Neg | Neg | Normal |
15 (C) | Neg | Th (sparse) | Neg | Neg/Neg | Neg | Normal |
16 (C) | Neg | Neg | Neg | Neg/Neg | Neg | Normal |
17 (C) | Neg | Neg | Neg | Neg/Neg | Neg | Normal |
18 (C) | Neg | Neg | Neg | Neg/Neg | Neg | Normal |
19 (C) | Neg | Th (rare) | Neg | Neg/Neg | Neg | Normal |
20 (C) | Neg | NFT (rare) | Neg | Neg/Neg | Neg | Hyperemia |
21 (C) | Neg | Th (rare) | Neg | Neg/Neg | Neg | Normal |
22 (C) | Neg | Neg | Neg | Neg/Pos | Neg | Normal |
23 (C) | Neg | Neg | Neg | Neg/Neg | Neg | Intimal thickening |
24 (C) | Neg | Th (sparse) | Neg | Neg/Neg | Neg | Normal |
25 (C) | Neg | Neg | Neg | Neg/Neg | Neg | Normal |
26 (C) | Neg | Neg | Neg | Neg/Neg | Neg | Normal |
Abbreviations: C, Control; Dys, Dystonia; H&E, Hematoxylin and Eosin; Neg, Negative; NFT, Neurofibrillary Tangle; Pos, Positive; SN, Substantia Nigra; TDP43, TAR DNA-binding Protein 43; Th, Thread