Table 5. Estimated Number of Pigmented Neuron Population and their Cellular and Subcellular Volumes in the SN of Dys and C Subjects. The table shows the estimated number and cell body, nuclear, and nucleolar volumes of pigmented neurons (mean±SD) in the SN of Dys and C across all considered subtypes. The significance of p-values is indicated for each type of comparison. The significance was established when p<0.01.
| Comparisons | Estimated Number of Pigmented Neurons (±SD) | Cell Body | Nuclear | Nucleolar |
|---|---|---|---|---|
|
| ||||
| Volume (µm3) | Volume (µm3) | Volume (µm3) | ||
| Dys (n = 13) vs. C (n = 13) | 496,601.6±130,009.4 vs. 648,925.7±169,700.2 (p = 0.0186) | 15,136.1±4,122.2 vs. 15,632.1±2,718.2 (ns) | 1,768.1±505.4 vs. 1,662.2±347.0 (ns) | 26.0±8.2 vs. 25.9±3.1 (ns) |
| *Dys (n = 8) vs. *C (n = 8) | 518,991.3± 139,210.6 vs. 725,432.2±16,531.8 (p = 0.0045) | 14,340.1±5,097.2 vs. 15,936.1±2,992.1 (ns) | 1,627.1±560.1 vs. 1,767.2±399.2 (ns) | 25.8±8.9 vs. 26.0±3.8 (ns) |
| Adulthood-onset Dys (n = 3) vs. C (n = 13) | 408,748.1±85,747.9 vs. 648,925.7±169,700.2 (p = 0.0366) | 13,669.1±3,557.2 vs. 15,936.1±2,992.1 (ns) | 1,661.1±491.9 vs. 1,662.2±347.0 (ns) | 24.0±6.8 vs. 25.9±3.1 (ns) |
| *Adulthood-onset Dys (n = 2) vs. *C (n = 8) | 408,748.1±85,747.9 vs. 725,432.2±16,531.8 (p = 0.0366) | 11,709.5±1,510.5 vs. 15,222.7±766.4 (ns) | 1,491.1±556.6 vs. 1,796.1±372.0 (ns) | 24.1±9.7 vs. 26.0±5.2 (ns) |
| Childhood-onset Dys (n = 10) vs. C (n = 13) | 503,648.9±124,734.1 vs. 648,925.7±169,700.2 (p = 0.0436) | 15,764.1±4,569.2 vs. 15,632.1±2,718.2 (ns) | 1,764±533.1 vs. 1,662±347.0 (ns) | 27.1±9.1 vs. 25.9±3.1(ns) |
| *Childhood-onset Dys (n = 6) vs. *C (n = 8) | 541,369.8±112,651.7 vs. 725,432.2±16,531.8 (p = 0.0192) | 15,216.7±1,373.2 vs. 15,222.7±766.4 (ns) | 1,671.7±400.9 vs. 1,796.1±372.0 (ns) | 25.6±5.2 vs. 26.0±5.2 (ns) |
| Childhood-onset Dys (n = 10) vs. Adulthood-onset Dys (n = 3) | 504,647.0±371,697.8 vs. 463,247.9±97,180.9 (ns) | 15,764.1±4,569.2 vs. 13,669.1±3,557.2 (ns) | 1,764±533.1 vs. 1,662.2±347.0 (ns) | 27.1±9.1 vs. 25.9±3.1 (ns) |
| *Childhood-onset Dys (n = 6) vs. *Adulthood-onset Dys (n = 2) | 535,589.0±371,697.8 vs. 512,103.1±67,582.0 (ns) | 15,216.7±1,373.2 vs. 11,709.5±1,510.5 (ns) | 1,671.7±400.9 vs. 1,796.1±372.0 (ns) | 25.6±5.2 vs. 26.0±5.2 (ns) |
| Generalized Dys (n = 6) vs. segmental/focal Dys (n = 7) | 514,023.1±98,491.31 vs. 481,668.9± 163,184.3 (ns) | 14,379.1±1,004.9 vs. 15,784.8±3,587.4 (ns) | 1,767.6±409.5 vs. 15,784.8±3,587.4 (ns) | 28.9±3.5 vs. 23.4±4.2 (ns) |
| *Generalized Dys (n = 5) vs. *segmental/focal Dys (n = 3) | 513,204.1±139,210.5 vs. 528,636.7±139,513.19 (ns) | 13,984.5±1,373.2 vs. 14,932.3±5,683.2 (ns) | 1,655.5±400.9 vs. 1,982.4±312.7 (ns) | 27.2±1.0 vs. 32.1±5.5 (ns) |
Abbreviations: C, Control; Dys, Dystonia; ns, not significant; SD, Standard Deviations; SN, Substantia Nigra.