Table 6.

Mediation analysis (Sobel test) to assess whether the effect of sense of coherence on health-related quality of life domains is mediated by depressive and/or anxiety symptoms

		Specific indirect effects
		via depressive symptoms	via anxiety symptoms
	Direct effect	Indirect effect; Z	Indirect effect; Z
Overall HRQoL	0.008a	-0.001; -0.648	0.005; 3.112b
Satisfaction with Health	0.002	0.001; 0.503	0.007; 3.325d
Physical HRQoL	0.003	0.002; 1.399	0.004; 3.372d
Mental HRQoL	0.004	0.003; 2.290a	0.003; 2.546a
Social relations HRQoL	0.002	0.002; 1.488	0.005; 3.328d
Environment HRQoL	0.003	0.002; 1.650	0.001; 1.578

Direct effect represents the independent effect of the predictor on the outcome after controlling for potential mediators; predictor: SOC; mediators: anxiety symptoms, depressive symptoms; control variables: sex, race, age, education, marital status, income, disease type, time since IBD diagnosis, surgery for IBD, relapse rate, and disease in remission.

^dP < 0.01,

^bP < 0.01,

^aP < 0.05 vs control. HRQoL: Health-related quality of life.