Table 2.
| Illness day | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | ≥ 14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Patient numbers | 4 | 16 | 47 | 87 | 114 | 132 | 127 | 120 | 86 | 45 | 28 | 11 | 6 | 75 |
| Signs | ||||||||||||||
| Temperature (°C) | 38 (37.2–40) | 38.5, 37.8–39.4 (36.6–40.6) | 38, 36.8–39.5 (36–40) | 38, 36.5–40 (36–40.2) | 37.1, 36–40 (36–40) | 36.8, 36–39 (36–39) | 36.6, 36–38.6 (36–39) | 36.5, 36–37.4 (36–38) | 36.5, 36–37.2 (35.8–36.8) | 36.5, 36–37.2 (36–38.5) | 36.5, 36–36.8 (36–37.5) | 36.5, 36.3–36.6 (36–37.8) | 35.8, 36.6, 37.8 | 36.5, 36–37 (36–37.8) |
| Pulse rate/minute | 95 (80–144) | 100 (74–112) | 88 (58–112) | 88 (62–128) | 84 (60–128) | 80 (52–120) | 80 (52–106) | 78 (58–94) | 78 (60–95) | 78 (60–105) | 80 (55–90) | 80 (76–85) | 76, 76, 82 | 80 (37–92) |
| Systolic BP (mmHg) | 110 (90–120) | 110 (90–110) | 110 (90–130) | 100 (85–128) | 100 (85–120) | 100 (80–130) | 100 (80–130) | 100 (90–120) | 100 (85–140) | 100 (70–130) | 105 (90–140) | 110 (100–120) | 105 (100–110) | 110 (90–140) |
| Diastolic BP (mmHg) | 70 (50–80) | 70 (60–80) | 70 (60–80) | 70 (50–90) | 60 (50–90) | 65 (50–80) | 60 (50–90) | 60 (50–80) | 70 (50–90) | 70 (50–80) | 70 (70–80) | 70 (60–70) | 65 (60–70) | 70 (60–90) |
| Pulse pressure (mmHg) | 40 (30–40) | 40 (30–40) | 40 (25–60) | 40 (25–65) | 40 (20–55) | 40 (20–60) | 40 (20–70) | 40 (30–60) | 40 (25–60) | 40 (20–60) | 40 (30–60) | 40 (30–50) | 40 (30–50) | 40 (30–50) |
| Hematological parameters | ||||||||||||||
| Total white cell count × 103/μL | 1.35, 3.5, 4.14, 8.84 | 2.57, 20.4–4.03 (1.27–4.36) | 2.45, 1.7–4.92 (1.2–5.8) | 2.55, 1.1–6.54 (0.89–8.51) | 2.09, 1.43–6.85 (1.16–8.34) | 4.56, 2.1–8.48 (1.57–10.55) | 5.05, 2.5–10.9 (2.02–12.4) | 5.43, 3.09–11.62 (2.53–15.9) | 5.31, 3.29–8.28 (2.61–9.51) | 4.93, 3.84–7.49 (3.64–8.84) | 6.26, 4.83–6.5 (3.79–9.73) | 5.21, 5.45, 7.11, 8.33 | 3.83, 5.49, 7.27 | 6.75, 4.01–9.2 (3.36–18.3) |
| Absolute neutrophil count/μL | 677; 940; 2,724; 7,478 | 1,170; 1,002–2,500 (239–3,163) | 1,299; 591–2,799 (400–4,261) | 1,080; 479–3,150 (330–4,032) | 1,050; 260–2,829 (178–3,679) | 1,038; 432–3,112 (330–4,552) | 1,326; 319–4,595 (250–6,890) | 1,476; 511–3,643 (218–10,176) | 1,728; 682–3,486 (312–4,363) | 1,699; 1,124–3,462 (647–4,031) | 1,994; 1,624–3,016 (1,336–3,876) | 1,705; 2,104; 2,787; 3,540 | 1,731; 2,300; 3,576 | 3,395; 1,982–4,950 (67–15,207) |
| Absolute lymphocyte count/μL | 179; 663; 919; 2,520 | 615; 568–1,018 (360–1,790) | 775; 490–1,989 (410–2,575) | 938; 349–2,642 (250–5,157) | 1,390; 530–3,897 (360–5,203) | 2,299; 739–4,754 (480–6,086) | 2,531; 1,111–6,108 (998–6,210) | 2,485; 1,320–5,291 (899–5,332) | 2,401; 1,371–4,419 (910–6,210) | 2,046; 1,488–3,167 (858–3,702) | 2,115; 1,729–2,355 (1,550–3,618) | 1,781; 2,630; 2,752; 3,073 | 1,639; 2,141; 2,188 | 2,288; 1,317–3,569 (40–4,433) |
| Neutropenia n/d (%) | 2/3 (66.6) | 7/12 (58.3) | 30/43 (69.8) | 55/81 (67.9) | 82/108 (75.9) | 86/127 (67.7) | 73/119 (61.3) | 54/112 (48.2) | 32/79 (40.5) | 10 (29.4) | 2/13 (15.4) | 0 | 0 | 1/57 (1.75) |
| Lymhopenia n/d (%) | 2/3 (66.6) | 8/12 (75) | 30/43 (69.7) | 46/81 (56.8) | 30/108 (27.8) | 9/127 (7.1) | 1/119 (0.8) | 1/112 (0.9) | 1 /79 (1.3) | 1/34 (2.9) | 0 | 0 | 0 | 2/57 (3.5) |
| Atypical lymphocytes n/d (%) | 0 | 1/12 (8.3) | 6/43 (13.95) | 18/81 (22.2) | 12/108 (11.1) | 6/127 (4.7) | 6/119 (5.04) | 20/112 (17.8) | 34/79 (43.04) | 18/34 (52.9) | 13 (23.08) | 4/4 (100) | 0 | 1/57 (1.75) |
| Immature neutrophils n/d (%) | 0 | 0 | 2/43 (4.6) | 8/81 (9.9) | 19/108 (17.6) | 19/127 (14.9) | 13/119 (10.9) | 12/112 (10.7) | 16/79 (20.2) | 7/34 (20.6) | 3/13 (23.1) | 2/4 (50) | 0 | 2/57 (3.5) |
| Biochemical parameters | ||||||||||||||
| AST (IU/L) | 37, 39, 87, 479 | 60, 64–75 (24–255) | 115, 50–250 (29–599) | 131, 60–455 (21–1,120) | 113, 44–773 (6–1,055) | 125, 73–338 (52–721) | 164, 122–282 (25–1,126) | 140, 72–372 (60–437) | 191, 72–346 (50–485) | 134, 123–265 (57–486) | 126.5, 83–153 (3.6–407) | 68, 88, 118, 166, 320 | 30, 121 | 50, 29–141 (27–230) |
| ALT (IU/L) | 16, 25, 64, 328 | 61, 27–73 (18–132) | 72, 32–180 (12–306) | 69, 19–264 (10–683) | 67, 22–360 (14–786) | 73, 45–236 (30–734) | 105, 54–222 (14–626) | 138, 75–401 (45–506) | 231, 63–434 (27–502) | 251, 103–374 (73–607) | 221, 149–268 (39–432) | 55, 174, 244, 350, 351 | 64, 288 | 84, 35–278 (21–418) |
| Total bilirubin | 6 | 16.4 | 8.55, 4.7–12 (3.4–21.1) | 7.1, 5.4–13 (3.9–28.6) | 7.35, 4.5–13 (3.9–14) | 9.9, 5–16.3 (3.2–18) | 10, 6.5–16.5 (5–21.7) | 8, 5–15 (3.6–17) | 10.3, 6.5–15.5 (4.3–22.4) | 10.9, 7–12 (3.9–14.1) | 8.5, 8–9.5 (5.9–10.9) | 11.8, 15 | 5.8, 16.9 | 10.5, 6.7–29.3 (5.1–88) |
| Albumin (g/L) | 42 | ND | 48, 45–51 (35–55) | 47, 44–51 (35–59) | 45, 40–52 (36–55) | 47, 42–53 (36–56) | 45, 43–52 (38–55) | 49, 44–52 (41–57) | 50.5, 45–53 (42–57) | 49, 48–51 (42–56) | 48, 47–50 (42–53) | 48, 51 | 51 | 54, 49–59 (48–63) |
| Blood clotting parameters | ||||||||||||||
| aPTT (seconds) | 32.9 | 26.7, 35.3 | 33.3, 31.2–38.8 (29.5–43.2) | 34.8, 31.5–39.5 (29.1–50.3) | 36.5, 29.4–45 (25.2–65.1) | 32.2, 28.4–41.5 (23.5–45) | 30.1, 27.9–33.2 (24–38.6) | 27.6, 23.8–32.4 (20.7–34) | 27.7, 24.4–28 (22.8–30.4) | 25.9, 25.3–26.8 (21.6–28.9) | 25.9, 24.8–26.6 (23.5–30.5) | 23.9 | 26.8 | 25.9, 28.3, 28.4 |
| PT (%) | 116.2 | 78.2, 114.4 | 105.9, 91.7–128.1 (81.3–155.5) | 114.4, 98.4–126 (82.4–134.8) | 120.9, 97–142 (79.2–158.4) | 126, 97–160 (90.5–167.7) | 134.8, 118.1–147.2 (101.3–152.6) | 130.3, 109.2–149.9 (95.7–171.6) | 132.4, 107.6–155 (73.6–161) | 123.9, 112.6–126 (91.7–152.6) | 129.2, 116.2–132.5 (88–144.1) | 121.9 | 149.9 | 116.4, 142, 152.6 |
| Fibrinogen | 1.5 | 0.9, 2.5 | 1.76, 1.24–2.07 (0.9–2.54) | 1.4, 1.2–2.1 (0.96–3.13) | 1.55, 1–2.17 (0.9–2.4) | 1.6, 1.23–2.47 (0.39–2.6) | 1.6, 1.2–1.97 (0.33–2.5) | 1.75, 1.4–2.53 (1.16–19.6) | 1.65, 1.5–2.19 (1.14–2.99) | 1.85, 1.7–2.2 (1.33–3.7) | 1.5, 1.3–2 (1.12–2.5) | 1.2 | 1.4 | 1.4, 1.6, 1.95 |
ALT = alanine transaminase; aPTT = activated partial thromboplastin time; AST = aspartate aminotransferase; BP = blood pressure; ND = no data; PT = prothrombin time.
*
Pulse rate and BP data are shown as median (full range); all other continuous data as median, interquartile range, and (full range).
†
≥ D14 includes data on and after illness day 14.