Table 1.
Symptomatic cases of proven or probable histoplasmosis
| Age (gender) | Probable location of infection | Visited bat habitat | Symptoms | Radiology | Travel partner with histoplasmosis† | Serology | Additional diagnostic tests | ||
|---|---|---|---|---|---|---|---|---|---|
| Fever | Respiratory* | ||||||||
| 1 | 29 (F) | Central America m/p Guatemala | Yes | Yes | Yes | 2 Nodules | Yes (#15) | Borderline | — |
| 2 | 28 (M) | Central America m/p Guatemala | Yes | Yes | Yes | Normal chest radiograph | No | Positive | — |
| 3 | 23 (M) | South America m/p Bolivia | Yes | Yes | Yes | 2 Nodules, 2 cavitated, LN | Yes (#4) | Positive | — |
| 4 | 22 (M) | South America m/p Bolivia | Yes | Yes | No | Several nodules, LN | Yes (#3) | Positive | — |
| 5 | 23 (M) | South America | No | Yes | Yes | Granuloma, LN | No | Positive | — |
| 6 | 54 (F) | Central America m/p Guatemala | Yes | Yes | Yes | Multiple nodules | Yes (#7) | Positive | — |
| 7 | 57 (M) | Central America m/p Guatemala | Yes | Yes | Yes | Multiple nodules | Yes (#6) | ND | — |
| 8 | 24 (M) | Guatemala | Yes | No | Yes | Nodules | No | Positive | — |
| 9 | 20 (F) | Central America m/p Guatemala | Yes | Yes | No | ND | No | Positive | — |
| 10 | 64 (M) | Bolivia or Brazil | No | Yes | No | 2 Nodules, LN | No | ND | Biopsy‡ |
| 11 | 57 (M) | Bolivia or Peru | No | Yes | No | RLL infiltrate | No | Positive | |
| 12 | 19 (F) | Peru | No | Yes | Yes | Multiple nodules | No | Negative | UrinaryAg§ |
| 13 | 46 (M) | Costa Rica | No | Yes | Yes | Multiple nodules | No | Positive | Biopsy∥ |
| 14 | 23 (F) | South America | No | Yes | Yes | 2 Nodules | No | Borderline | |
Ag = antigen; F = female; LN = lymphadenopathy (hilar or mediastinal); M = male; m/p = most probably; ND = no data; RLL = right lower lobe.
*
Cough, dyspnea, chest pain.
†
Proven or probable.
‡
Serology uninterpretable because of anticomplementary activity, diagnosis based on biopsy of mediastinal lymph nodes showing necrotizing granulomata, with growth of Histoplasma capsulatum on culture of biopsy tissue.
§
Urinary Histoplasma antigen positive.
∥
Transbronchial biopsies showed necrotizing granulomata and non-budding yeast forms.