Table 1.
Discrete typing unit (DTU), source of isolation, geographical origin, infectivity rate (%INF), parasitemia clearance rate (%PC), and profile of in vivo susceptibility to benznidazole of Trypanosoma cruzi strains studied
| Strains of T. cruzi | DTU | Source of isolation | Geographical origin | %INF | % PC | Susceptibility to BZ |
|---|---|---|---|---|---|---|
| MHOM/BR/2008/AM49 | TcI | Acute phase patient | Coari/AM* | 100.0 (7/7) | 0.0 (0/6) | R |
| MDID/BR/2007/AM45 | TcI | Didelphis marsupialis | Manaus/AM | 71.4 (5/7) | 16.7 (1/6) | R |
| MDID/BR/2007/AM44 | TcI | Didelphis marsupialis | Manaus/AM | 71.4 (5/7) | 42.9 (3/7) | IS |
| MPHI/BR/2007/AM34 | TcI | Philander opossum | Manaus/AM | 100.0 (7/7) | 57.1 (4/7) | IS |
| TPIS/BR/2007/AM33 | TcI | Rhodnius pictipes | Manaus/AM | 100.0 (6/6) | 85.7 (6/7) | S |
| MDID/BR/2007/AM31 | TcI | Didelphis marsupialis | Manaus/AM | 57.1 (4/7) | 100.0 (7/7) | S |
| MHOM/BR/2007/PR1219 | TcII | Chronic phase patient | Maringá/PR† | 100.0 (13/13) | 0.0 (0/6) | R |
| MHOM/BR/2007/BS48 | TcII | Chronic phase patient | Colorado/PR | 100.0 (9/9) | 42.9 (3/7) | IS |
| MHOM/BR/2009/PR2259 | TcII | Chronic phase patient | Maringá/PR | 90.0 (9/10) | 100.0 (8/8) | S |
| MHOM/BR/2010/PR1226 | TcII | Chronic phase patient | Virgem da Lapa/MG‡ | 90.0 (9/10) | 100.0 (6/6) | S |
| MHOM/BR/2007/AM15 | TcIV | Acute phase patient | Coari/AM | 87.5 (7/8) | 0.0 (0/5) | R |
| MHOM/BR/2007/AM14 | TcIV | Acute phase patient | Coari/AM | 90.0 (9/10) | 14.3 (1/7) | R |
| TROB/BR/2009/AM57 | TcIV | Rhodnius robustus | Apuí/AM | 100.0 (9/9) | 28.6 (2/7) | R |
| MHOM/BR/2010/AM64 | TcIV | Acute phase patient | SIRN§/AM | 100.0 (9/9) | 28.6 (2/7) | R |
| MHOM/BR/2010/AM62 | TcIV | Acute phase patient | SIRN/AM | 100.0 (13/13) | 42.9 (3/7) | IS |
| MHOM/BR/2010/AM67 | TcIV | Acute phase patient | SIRN/AM | 100.0 (10/10) | 50.0 (4/8) | IS |
| MHOM/BR/2010/AM69 | TcIV | Acute phase patient | SIRN/AM | 77.8 (7/9) | 85.7 (6/7) | S |
| MHOM/BR/2010/AM68 | TcIV | Acute phase patient | SIRN/AM | 80.0 (8/10) | 100.0 (7/7) | S |
Brazilian states of
*
Amazonas;
†
Paraná;
‡
Minas Gerais; and
§
Santa Isabel do Rio Negro.
R = resistent; IS = intermediate sensitivity; S = sensitive.