Table 6.
Number and percentage of parasitized organs (in which DNA was detected by qPCR) in mice inoculated with Trypanosoma cruzi I, II, and IV, treated with TBZ during acute phase and untreated controls, at different stages of infection
| Stage of infection | TcI (N = 288) | TcII (N = 96) | TcIV (N = 240) | |||
|---|---|---|---|---|---|---|
| NT (N = 144, 48/stage) | TBZ (N = 144) | NT (N = 48, 16/stage) | TBZ (N = 48) | NT (N = 120, 40/stage) | TBZ (N = 120) | |
| eAP* | 24 (50.0) | 23 (47.9) | 6 (37.5) | 1 (6.3)† | 21 (52.5) | 12 (30.0)† |
| lAP‡ | 33 (68.8)§ | 22 (45.8)† | 10 (62.5) | 2 (12.5)† | 17 (42.5) | 13 (32.5) |
| CP¶ | 25 (52.1) | 25 (52.1) | 6 (37.5) | 6 (37.5) | 19 (47.5) | 14 (35.0) |
*
Early acute phase (one day after the peak of parasitemia);
†
Significant difference between untreated controls (NT) and benznidazole treated mice (TBZ), and
§
among DTUs.
‡
Late acute phase (30 days after inoculation).
¶
Chronic phase (100 days after inoculation).
qPCR = real time-polymerase chain reaction.