Mean total asexual parasite dynamics (A) and gametocyte dynamics (B) following initiation of treatment. Infections were initiated with either very abundant (106, blue lines); abundant (105, red lines); rare (103, yellow lines); and very rare (101, green lines) inoculations of resistant parasites, contemporaneously with 106 susceptible parasites. Drug treatment was given on days 6–9 postinfection. Data are means (± standard error) of the total density of up to 10 mice.