Figure 2. The Mendelian randomization estimate of the effect of T2D on CHD using a random-effects model.
For each of the 26 non-pleiotropic SNPs (Table 1), the Forest plot shows the estimate of the effect of genetically increased T2D risk on CHD risk, as assessed for each SNP. Also shown for each SNP is the 95% confidence interval (black line segment) of the estimate and the inverse-variance weight (% proportional to the size of the grey square) in the random-effects meta-analysis.