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. 2015 May 28;6:7203. doi: 10.1038/ncomms8203

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(a) Outline of myeloid progenitor culture and induction strategy in progenitor expansion medium. (b) Percentage and number of up- and downregulated genes in myeloid progenitor cultures after overnight RUNX1-ETO induction compared with all expressed genes. The numbers over the bars represent the number of genes changing expression. (c) Principal component analysis demonstrating the differential effect of RUNX1-ETO induction on gene expression in four different cell types induced at different stages (HE, HE2, CD41⁺KIT⁺Tie2⁻ progenitors and myeloid progenitors). RUNX1-ETO-induced gene expression changes in myeloid progenitors is markedly different from that in early progenitors where RUNX1-ETO was induced in the HE stage. (d) Heat map demonstrating differential gene expression change of direct RUNX1-ETO targets in the different cell types after RUNX1-ETO induction. (e) Venn diagram demonstrating that there is little overlap between RUNX1-ETO-target genes changing expression in the different cell types.