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. 2015 May 28;6:7203. doi: 10.1038/ncomms8203

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(a) Expression of RUNX1-ETO in the HE leads to a block in the EHT. Left panel: endothelial gene expression program with low levels of RUNX1 and expression of endothelial genes. Right panel: haematopoietic gene expression program where haematopoietic genes are upregulated and endothelial genes are downregulated. The induction of RUNX1-ETO leads to a lack of upregulation of haematopoietic genes (indicated as ‘off') but also a failure to repress the endothelial genes (indicated as ‘on'). (b) Expression of RUNX1-ETO in myeloid progenitors leads to enhanced self-renewal. Left panel: stem cell gene expression program including early haematopoietic regulator genes, this is normally only transiently observed in ES-derived cells (see Fig.3 and Supplementary Fig. 3). Right panel: myeloid gene expression program found in committed myeloid progenitor cells. Here the stem cell program is downregulated, while the myeloid program is upregulated. RUNX1-ETO interferes with this downregulation by targeting RUNX1 sites at myeloid regulator genes (indicated as ‘low'), which then in turn fail to downregulate the stem cell program (indicated as ‘high').