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Effect of kaempferol on bradykinin-induced relaxations in the presence of (A) NOS inhibitor or (B) GC inhibitor. Rings from porcine coronary arteries were incubated with L-NAME (10−4 M) or ODQ (10−5 M), in the presence of kaempferol (3 × 10−6 M) or the vehicle control (ethanol, 0.1%) for 30 min. Rings were then contracted with U46619 (3 × 10−8 M) before bradykinin was added cumulatively. n = 6–7. *P < 0.05, significantly different from the group without kaempferol.
