Figure 7.
Effect of kaempferol on whole-cell current in PCASMC. Whole-cell currents were studied at different voltages generated by stepwise depolarization, in steps of 10 mV, from −70 to +70 mV with a holding potential of −70 mV. Currents were recorded under (A) control conditions, (B) in the presence of kaempferol (10−5 M) and (C) after washout of kaempferol. (D) Average current–voltage relationships, with the current normalized to cell capacitance and expressed as pA/pF, under control conditions and in the presence of kaempferol (10−5 M) with or without iberiotoxin (large-conductance calcium-activated potassium channel inhibitor, 10−7 M), and (E) percentage increase from the control condition of the current recorded at the end of the pulse at +70 mV. n = 3–6. *P < 0.05, significantly different from the control group.