Table 1.
Effects of acute treatment with different flavonoids on the EC50 and Emax values of concentration–relaxation curves of bradykinin (10−11 to 10−6 M) in porcine coronary arteries contracted by U46619 (3 × 10−8 M)
| Treatment | EC50 (log M) | Emax (%) |
|---|---|---|
| Control | −8.3 ± 0.1 | 102 ± 2.2 |
| Ethanol (0.1%) | −8.4 ± 0.1 | 109 ± 2.1 |
| Kaempferol (3 × 10−6 M) | −8.8 ± 0.1* | 112 ± 3.9 |
| Kaempferol (10−5 M) | −8.8 ± 0.1* | 114 ± 2.0* |
| Apigenin (10−5 M) | −8.1 ± 0.1 | 110 ± 1.2 |
| Myricetin (10−5 M) | −7.9 ± 0.2 | 96 ± 3.0 |
| Quercetin (10−5 M) | −8.4 ± 0.1 | 108 ± 1.8 |
| Rutin (10−5 M) | −8.3 ± 0.2 | 97 ± 2.2 |
n = 4–8 in each group.
*
P < 0.05, significantly different from the control group.